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PAC-1

Cat No.
CEI-0986
Description
Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 µM). Also activates procaspase-7 in a less efficient manner (EC50 = 4.5 µM). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50 values are 0.003 - 1.41 and 5.02 - 9.98 µM respectively). PAC-1 had an IC50 value of 3 nM for induction of cell death, whereas in cells from adjacent normal tissue IC50 values of 3.2-8.5 µM were observed
Abbr
PAC-1
Appearance
A crystalline solid.
CAS No.
315183-21-2
Molecular Weight
392.5 Da
Purity
>99%
Stability
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Targets
Protease
Molecular Formula
C23H28N4O2
Solubility
Soluble to 75 mM in 1eq. HCl and to 100 mM in DMSO
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