Products

Enzymes for Research, Diagnostic and Industrial Use

PD153035 HCL

Cat No.
CEI-0016
Description
PD153035 can inhibit epidermal growth factor (EGF) receptor tyrosine kinase with Ki of 6 pM.
CAS No.
183322-45-4
Molecular Weight
396.67
Purity
>99%
Storage
2 years at -20 centigrade
Targets
EGFR
Molecular Formula
C16H14BrN3O2.HCl
Chemical Name
N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride
Solubility
DSMO 0.5 mg/mL Water
In vitro
PD153035 can inhibit epidermal growth factor (EGF) receptor tyrosine kinase with Ki of 6 pM. PD153035 can potently suppresses tyrosine phosphorylation of the EGF receptor in A431 cells at nanomolar concentrations. PD153035 inhibits EGF-dependent EGF receptor phosphorylation and suppresses the proliferation and clonogenicity of a wide panel of EGF receptor-overexpressing human cancer cell lines. EGF receptor autophosphorylation in response to exogenous EGF was completely inhibited at PD153035 concentrations of >75 nM in cells overexpressing the EGF receptor.
In vivo
In A431 human epidermoid tumors grown as xenografts in immunodeficient nude mice, PD153035(80 mg/kg) suppresse the tyrosine phosphorylation of the EGF receptor rapidly by 80-90% in the tumors.
Download Datasheet:



Inquiry
Realted Products
Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogCEI-0013
ProductNameOSI-420
EC No.
CAS No.183320-51-6
Source
CatalogCEI-0014
ProductNameWZ4002
EC No.
CAS No.1213269-23-8
Source
CatalogCEI-0018
ProductNameLapatinib
EC No.
CAS No.231277-92-2
Source
CatalogCEI-0024
EC No.
CAS No.257933-82-7
Source
+ See More >>
Online Inquiry
Name:
*Phone:
*E-mail Address:
Country:
Company/Institution:
*Products or Services Interested:
Quantity:
Project Description:
Our Products are Not Intended for Private Therapeutic Use!
*Verification Code:
Please input "enzymes"(case insensitive) as verification code.

Welcome! For price inquiries, please feel free to contact us through the form below through the form on the left side. We will get back to you as soon as possible.

Sitemap  Privacy Policy
Copyright ©2011 - 2017 Creative Enzymes.
Contact Us 45-1 Ramsey Road, Shirley, NY 11967, USA
Email: info@creative-enzymes.com
Tel: 1-631-562-8517 1-631-448-7888
Fax: 1-631-938-8127
Distributors To view the contact information for a specific location, select the desired country: