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PD173955

Cat No.
CEI-1099
Description
PD173955 is an ATP-competitive, dual Src/Abl kinase inhibitor. It is a potent inhibitor of Bcr-Abl with an IC50 of 1-2 nM in kinase inhibition assays. In cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 al
Abbr
PD173955(BCR, ABL1, SRC)
Alias
ALL, BCR1, CML, D22S11, D22S662, PHL
Product Overview
ATP-competitive, dual Src/Abl kinase inhibitor
CAS No.
260415-63-2
Molecular Weight
443.35
Purity
> 95%
Stability
2 years -20 centigrade Powder
1 month -4 centigrade in DMSO
More than one month -80 centigrade in DMSO
Storage
4 centigrade
Synonyms
ALL, BCR1, CML, D22S11, D22S662, PHL
Targets
Bcr-Abl, c-Src
IC50
2-35
Molecular Formula
C21H16Cl2N4OS
Chemical Name
6-(2,6-dichlorophenyl)-8-methyl-2-(3-(methylthio)phenylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
Solubility
DMSO > 112mg/mL Water >1mg/mL Ethanol > 4mg/mL
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