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PDE4A4B active from Human, Recombinant


Cat No.
NATE-0524
Description
Human PDE4A4B, also known as PDE4A isoform 1 (GenBank Accession No. NM_001111307) amino acids 2-end with N-terminal GST-tag, MW= 124 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Abbr
PDE4A, Recombinant (Human)
Alias
PDE4A10; PDE4A
Source
Baculovirus infected Sf9 cells
Species
Human
Applications
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Product Overview
Human PDE4A4B, also known as PDE4A isoform 1 (GenBank Accession No. NM_001111307) amino acids 2-end with N-terminal GST-tag, MW= 124 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Form
aqueous solution
Molecular Weight
mol wt 124 kDa
Purity
> 40% (SDS-PAGE)
Unit Definition
One unit is defined as the amount of enzyme that will convert 1 pmole of 3?, 5?-cAMP to 5?-AMP per min at 37°C.
Storage
−70°C
Pathway
DARPP-32 events, organism-specific biosystem; G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Morphine addiction, organism-specific biosystem; Morphine addiction, conserved biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem
Function
3,5-cyclic-AMP phosphodiesterase activity; 3,5-cyclic-nucleotide phosphodiesterase activity; cAMP binding; drug binding; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity
Synonyms
DPDE2; PDE46; phosphodiesterase 4A, cAMP-specific; PDE4A10; PDE4A
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