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Enzymes for Research, Diagnostic and Industrial Use

PF-04929113 (SNX-5422)

Cat No.
CEI-0339
Description
PF-04929113 (SNX-5422)
CAS No.
908115-27-5
Molecular Weight
521.53
Purity
>99%
Storage
2 years at -20 centigrade
Targets
HSP90
Molecular Formula
C25H30F3N5O4
Solubility
No
In vitro
As a selective HSP90 inhibitor, PF-04929113 (SNX-5422) can potently inhibit HSP90 with Kd of 41 nM. PF-04929113 (SNX-5422) also shows inhibition to Her-2 degradation with IC50 of 37 nM.PF-04929113 can inhibit cell lines MCF-7, SW620, K562, SK-MEL-5, and SK-MEL-5 with IC50 of 16 nM, 19 nM, 23 nM, 25 nM, and 51 nM.
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