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PF-543 Citrate

Cat No.
CEI-1475
Product Overview
PF-543 is a novel cell-permeant inhibitor of SphK1.PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling.
CAS No.
1415562-83-2
Molecular Weight
657.73
Purity
0.98
Storage
Store at -20°C
Synonyms
PF543 Citrate; PF 543 Citrate
Targets
SphK1
Molecular Formula
C33H39NO11S
Chemical Name
[(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol; 2-hydroxypropane-1,2,3-tricarboxylic acid
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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