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PHA-665752

Cat No.
CEI-0075
Description
PHA-665752 can inhibit c-MET with IC50 of 9 nM.
CAS No.
477575-56-7
Molecular Weight
641.61
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
c-MET
Molecular Formula
C32H34Cl2N4O4S
Chemical Name
(R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one
Solubility
DMSO 128 mg/mL Water
In vitro
PHA-665752 can inhibit c-MET with IC50 of 9 nM. For cell lines:(1) PHA-665752 can decrease the numbers of premalignant lung lesions and induced apoptosis in tumor cells and vascular endothelial cells within lesions.PHA-665752 induced apoptosis of a lung adenocarcinoma cell line derived from Kras(LA1) mice (LKR-13) and a murine lung endothelial cell line (MEC). And PHA-665752 inhibited lung tumorigenesis in Kras(LA1) mice. (2) PHA-665752 triggers massive apoptosis in 5 of 5 gastric cancer cell lines with MET amplification.
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