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Enzymes for Research, Diagnostic and Industrial Use

PHA-680632

Cat No.
CEI-0335
Description
PHA-680632
CAS No.
398493-79-3
Molecular Weight
501.62
Purity
>99%
Storage
2 years at -20 centigrade
Targets
Aurora A
Molecular Formula
C28H35N7O2
Solubility
No
In vitro
PHA-680632 potently inhibits all three Aurora kinases (A, B, and C) with IC50 values of 27, 135, and 120 nM, respectively. PHA-680632 (0.5 uM) causes polyploidy in tumor cells. The mechanism of action of PHA-680632 is in agreement with inhibition of Aurora kinases. PHA680632 in association with radiation leads to additive effects in cancer cells, especially in the p53-deficient cells.
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