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Enzymes for Research, Diagnostic and Industrial Use

PI-103

Cat No.
CEI-0112
Description
PI-103 can inhibit p110-alpha, p110-beta, p110-delta, p110-gamma, mTORC1, mTORC2, DNA-PK and PI3KC2-beta with IC50 of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, 83 nM, 2 nM and 20 nM.
CAS No.
371935-74-9
Molecular Weight
348.36
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
p110-alpha/p110-beta, p110-delta/p110-gamma, mTORC1/mTORC2, DNA-PK, PI3KC2-beta
Molecular Formula
C19H16N4O3
Chemical Name
Phenol, 3-[4-(4-morpholinyl)pyrido[3,2:4,5]furo[3,2-d]pyrimidin-2-yl]-
Solubility
DMSO 24 mg/mL Water
In vitro
As a potent inhibitor, PI-103 can inhibit p110-alpha and DNK-PK with IC50 of 8 nM and 2 nM. Besides inhibiting p110-alpha and DNK-PK,PI-103,an ATP-competitive inhibitor,shows inhibition to other targets including mTORC1,PI3-KC2-beta,p110-delta,mTORC2,p110-beta,and p110-gamma.
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