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Enzymes for Research, Diagnostic and Industrial Use

PIK-75

Cat No.
CEI-0135
Description
PIK-75 can inhibit p110 alpha and DNA-PK with IC50 of 5.8 nM and 2 nM.
CAS No.
372196-77-5
Molecular Weight
488.74
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
p110 alpha, DNA-PK
Molecular Formula
C16H14BrN5O4S.HCl
Chemical Name
(E)-N-((6-bromoH-imidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide hydrochloride
Solubility
DMSO 3 mg/mL Water
In vitro
PIK-75 is a selective inhibitors of p110 alpha. PIK-75 can block the phosphorylation of PKB (akt) induced by insulin on both Ser 473 and Thr 308 in CHO-IR cells in a dose-dependent manner with an IC 50 of 78 nM. In 3T3-L1 pre-adipocytes, inhibition of p110-alpha by PIK-75 decreases the insulin-induced phosphorylation of PKB on both sites (Ser 473 and Thr 308 ).
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