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PX 12

Cat No.
CEI-0677
Description
PX-12 is an irreversible inhibitor of thioredoxin-1 (TRX-1) (Ki = 31 µM). It decreases the expression of HIF-1α ;, VEGF and iNOS (IC50 values are 7.2, ~10 and 18.1 μM respectively). Also known to display antitumor activity and inhibits tubulin polymerization in vitro.
Alias
IV-2
Appearance
White solid
Product Overview
An irreversible inhibitor of thioredoxin-1 (TRX-1)
CAS No.
141400-58-0
Molecular Weight
213.23
Purity
>95% by HPLC
Storage
-20 centigrade
Synonyms
IV-2
Targets
TXN1
Molecular Formula
C 7 H 12 N 2 S 2
Chemical Name
2-[(1-Methylpropyl)dithio]-1H-imidazole
Solubility
DMSO (20 mg/ml) or water (5 mg/ml)
Shipping Conditions
Gel pack
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