Products

Enzymes for Research, Diagnostic and Industrial Use

Pelitinib (EKB-569)

Cat No.
CEI-0024
Description
Pelitinib (EKB-569)
Alias
WAY-EKB 569
CAS No.
257933-82-7
Molecular Weight
467.92
Purity
>99%
Storage
2 years at -20 centigrade
Synonyms
WAY-EKB 569
Targets
EGFR
Molecular Formula
C24H23ClFN5O2
Solubility
No
In vitro
EKB-569 (Pelitinib), an irreversible EGFR tyrosine kinase inhibitor has shown potential therapeutic efficiency in solid tumors. In SCC-4 and SCC-9 cells, Pelitinib inhibited IR-induced NF-kB, telomerase activity and hTERT transactivation. Ionizing radiation-induced telomerase activity is regulated at the transcriptional level by triggering TERT promoter activation. Pelitinib potently inhibits the proliferation of normal human keratinocytes (NHEK), as well as A431 and MDA-468 tumor cells with IC50 of 61 nM, 125 nM, and 260 nM. The ABCG2 multidrug transporter confers resistance to gefitinib and pelitinib. In breast and ovarian cancer cells, although ErbB phosphorylation was reduced by pelitinib and canertinib, activation of the AKT/mTOR pathway remained essentially unaltered in drug-resistant cells.
Download Datasheet:



Inquiry
Realted Products
Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogCEI-0013
ProductNameOSI-420
EC No.
CAS No.183320-51-6
Source
CatalogCEI-0014
ProductNameWZ4002
EC No.
CAS No.1213269-23-8
Source
CatalogCEI-0016
ProductNamePD153035 HCL
EC No.
CAS No.183322-45-4
Source
CatalogCEI-0018
ProductNameLapatinib
EC No.
CAS No.231277-92-2
Source
+ See More >>
Online Inquiry
Name:
*Phone:
*E-mail Address:
Country:
Company/Institution:
*Products or Services Interested:
Quantity:
Project Description:
Our Products are Not Intended for Private Therapeutic Use!
*Verification Code:
Please input "enzymes"(case insensitive) as verification code.

Welcome! For price inquiries, please feel free to contact us through the form below through the form on the left side. We will get back to you as soon as possible.

Sitemap  Privacy Policy
Copyright ©2011 - 2017 Creative Enzymes.
Contact Us 45-1 Ramsey Road, Shirley, NY 11967, USA
Email: info@creative-enzymes.com
Tel: 1-631-562-8517 1-631-448-7888
Fax: 1-631-938-8127
Distributors To view the contact information for a specific location, select the desired country: