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Enzymes for Research, Diagnostic and Industrial Use

pikromycin synthase

Cat No.
EXWM-0784
Description
A heme-thiolate protein (cytochrome P-450). Involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit. With narbomycin it hydroxylates at either C-12 to give pikromycin or C-14 to give neopikromycin or both positions to give narvopikromycin. With 10-deoxymethymycin it hydroxylates at either C-10 to give methymycin or C-12 to give neomethymycin or both positions to give novamethymycin.
Form
Liquid or lyophilized powder
Enzyme Commission Number
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Synonyms
PikC; CYP107L1
Reaction
(1) narbomycin + NADPH + H+ + O2 = pikromycin + NADP+ + H2O; (2) narbomycin + NADPH + H+ + O2 = neopikromycin + NADP+ + H2O; (3) narbomycin + 2 NADPH + 2 H+ + 2 O2 = novapikromyin + 2 NADP+ + 2 H2O; (4) 10-deoxymethymycin + NADPH + H+ + O2 = methymycin + NADP+ + H2O; (5) 10-deoxymethymycin + NADPH + H+ + O2 = neomethymycin + NADP+ + H2O; (6) 10-deoxymethymycin + 2 NADPH + 2 H+ + 2 O2 = novamethymycin + 2 NADP+ + 2 H2O
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
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