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Purvalanol B

Cat No.
CEI-1104
Description
Cyclin-dependent kinase inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Purvalanol B has also been shown to have antiproliferative properties, mediated by p42/p44 MAPK.
Abbr
Purvalanol B(CDK1, cyclin B, CDK2, CCNA2, cyclin E, CDK4, CCND1, CDK5, IL12A, )
Alias
CDC2, CDC28A, P34CDC2
Product Overview
Cyclin-dependent kinase inhibitor
CAS No.
212844-54-7
Molecular Weight
432.9
Purity
> 95%
Stability
2 years -20 centigrade Powder
1 month -4 centigrade in DMSO
More than one month -80 centigrade in DMSO
Storage
4 centigrade
Synonyms
CDC2, CDC28A, P34CDC2
Targets
cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1, cdk5-p35
Molecular Formula
C20H25ClN6O3
Chemical Name
(R)-2-chloro-4-(2-(1-hydroxy-3-methylbutan-2-ylamino)-9-isopropyl-9H-purin-6-ylamino)benzoic acid
Solubility
DMSO > 112mg/mL Water >1mg/mL Ethanol > 4mg/mL
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