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Rocaglamide

Cat No.
CEI-0589
Description
An immunosuppressant and a potent inhibitor of NF-κB activation in T cells, with an almost complete inhibition at 200 nM. Suppresses cytokine production (IFN-γ, TNF-α, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-κB and AP-1 activities. Also induces mitochondria-mediated apoptosis in leukemia cells and sensitizes CD95/CD95L-mediated apoptosis in malignant T-cells by differential regulation of CD95L and c-FLIP expression.
Alias
Rocaglamide A
Appearance
White solid
Product Overview
An immunosuppressant
CAS No.
84573-16-0
Molecular Weight
228.2
Purity
>98% by HPLC
Storage
-20 centigrade
Synonyms
Rocaglamide A
Targets
NFKB1
Molecular Formula
C₂₉H₃₁NO₇
Solubility
DMSO (100 mM) or H2O (100 mM)
Shipping Conditions
Gel pack
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