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Rotenone

Cat No.
CEI-0571
Description
A broad spectrum insecticide that is cell-permeable and brain-permeable. Acts as a mitochondrial electron transport chain inhibitor (IC50 = 1.7 - 2.2 µM at complex I). Inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC50 = 3.4 nM). Neurotoxic agent that has also been used successfully to reproduce Parkinsons-like characteristics in in-vitro slice culture models.
Appearance
White to off-white solid
Product Overview
A mitochondrial electron transport chain inhibitor
CAS No.
83-79-4
Molecular Weight
678.48
Purity
>98% by NMR
Storage
-20 centigrade
Targets
mirotubule
Molecular Formula
C 23 H 22 O 6
Chemical Name
(2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-][1]benzopyran-6(6aH)-one
Solubility
DMSO (100 mM) or Ethanol (50 mM)
Shipping Conditions
Gel pack
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