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SANT-1

Cat No.
CEI-0664
Description
Cell-permeable. A potent inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (Kd = 1.2 nM). Inhibits smoothened agonist effects with an IC 50 of 20 nM in Shh-LIGHT2 cells. SANT-1 inhibits both wild type and oncogenic Smo with equal potency.
Appearance
White to off-white solid
Product Overview
A potent inhibitor of Sonic hedgehog (Shh) signaling
CAS No.
304909-07-7
Molecular Weight
543.54
Purity
>98% by NMR
Storage
-20 centigrade
Targets
SHH
Molecular Formula
C 23 H 27 N 27
Chemical Name
N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4- (phenylmethyl)-1-piperazinamine
Solubility
DMSO
Shipping Conditions
Gel pack
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