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SB 939

Cat No.
CEI-0507
Description
An orally available pan-histone deacetylase (HDAC) inhibitor binding all HDAC isozymes with similar affinity (Kis = 16-28 nM) with the exception of HDAC6 and 7 (Kis = 247 and 104 nM, respectively). SB 939 demonstrates good bioavailability in vivo and significantly inhibits tumor growth in various xenograft mouse models at doses ranging from 25-100 mg/kg.
Alias
Pracinostat
Appearance
Pale yellow solid
Product Overview
A pan-HDAC inhibitor
CAS No.
929016-96-6
Molecular Weight
376.86
Purity
>98% by HPLC
Storage
-20 centigrade
Synonyms
Pracinostat
Targets
HDAC
Molecular Formula
C20H30N4O2
Chemical Name
3-​[2-​butyl-​1-​[2-​(diethylamino)ethyl]-​1H-​benzimidazol-​5-​yl]-​N-​hydroxy-​2E-​propenamide
Solubility
DMSO (~ 50 mM)
Shipping Conditions
Gel pack
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