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Enzymes for Research, Diagnostic and Industrial Use

SB743921

Cat No.
CEI-1521
Description
SB743921 is an inhibitor of kinesin spindle protein (KSP) with a Ki value of 0.1 nM.
Product Overview
SB743921 is an inhibitor of kinesin spindle protein (KSP) with Ki value of 0.1nM. As an inhibitor of mitotic kinesin KSP, SB743921 causes cell cycle arrest in mitosis, results in cell death. SB743921 is developed to treat for cancers. SB743921 is a potent and selective inhibitor. In the affinity assays, SB743921 shows Ki values of 0.1nM and 0.12nM for human KSP and mouse KSP, respectively. It has no affinity with other kinesins. In the cellular assay, SB743921 exerts anti-proliferation efficacy in SKOV3, Colo205, MV522 and MX1 with IC50 values of 0.02nM, 0.07nM, 1.7nM and 0.06nM. Moreover, SB743921 is shown to have activity against human tumor xenografts Colo205, MCF-7, SK-MES, H69, OVCAR-3, HT-29, MDA-MB-231 and A2780.SB743921 is also effective against P388 lymphocytic leukemia xenografts in mice.
CAS No.
940929-33-9
Molecular Weight
553.53
Purity
0.98
Storage
Store at-20°C
Targets
KSP (MX1 cells); KSP (Colo205 cells); KSP; KSP (SKOV3 cells); KSP (MV522 cells); KSP (P388 cells)
IC50
0.06 nM; 0.07 nM; 0.1 nM(Ki); 0.2 nM; 14.4 nM; 14.4 nM
Molecular Formula
C31H34Cl2N2O3
Chemical Name
N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxochromen-2-yl)-2-methylpropyl]-4-methylbenzamide; hydrochloride
Solubility
Soluble in DMSO > 10 mM
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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