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Enzymes for Research, Diagnostic and Industrial Use

S-Ruxolitinib (INCB018424)

Cat No.
CEI-1074
Description
S-Ruxolitinib is the chirality of INCB018424, which is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Phase 3.
Abbr
S-Ruxolitinib (INCB018424)(JAK1, JAK2 )
Alias
JAK1A, JAK1B, JTK3
CAS No.
941685-37-6
Molecular Weight
306.37
Purity
0.9981
Storage
2 years -20 centigrade Powder 2 weeks4centigradein DMSO 6 months-80centigradein DMSO
Synonyms
JAK1A, JAK1B, JTK3
Targets
JAK1, JAK2
IC50
3.3 nM, 2.8 nM
Molecular Formula
C17H18N6
Chemical Name
1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βS)-
Solubility
DMSO 61 mg/mL
Water 5 mg/mL
Ethanol 61 mg/mL
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