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SU-4312

Cat No.
CEI-0976
Description
Potent and selective inhibitor of VEGF receptor tyrosine kinase (Flk-1, KDR). Inhibits unactivated kinase 100-fold greater (IC50=0.04 uM) than activated kinase (IC50=4.0 uM ). Weak inhibitor of PDGF receptor tyrosine kinase (IC50=19.4 uM). Inhibits endothelial cell activation and angiogenesis in a mouse model of Alzheimers disease.
Abbr
SU-4312(KDR, PDGFRB)
Alias
1. 3-(4-Dimethylaminobenzylidene)-1, 3-dihydroindol-2-one 2. DMBI
Appearance
Orange powder
Product Overview
VEGFR; PDGFR inhibitor
CAS No.
5812-07-7
Molecular Weight
264.3
Purity
>98% (TLC); NMR (Conforms)
Synonyms
1. 3-(4-Dimethylaminobenzylidene)-1,3-dihydroindol-2-one 2. DMBI
Targets
VEGFR, PDGFR
Molecular Formula
C17H16N2O
Solubility
May be dissolved DMSO (25 mg/ml)
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