Products

Enzymes for Research, Diagnostic and Industrial Use

Smo Antagonist, SA9

Cat No.
CEI-0658
Description
SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC50 = 19 µM). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the β-galactosidase activity (IC50 = 1.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Appearance
Liquid
Product Overview
A Hedgehog (Hh) signaling pathway antagonist
Molecular Weight
860
Purity
>95% by HPLC
Storage
-20 centigrade
Targets
SMO
Molecular Formula
C 27 H 28 ClN 5 O 2
Chemical Name
3-(3-(4-Fluorophenyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl-N-(3-methylphenethyl)propanamide
Shipping Conditions
Gel pack
Download Datasheet:



Inquiry
Realted Products
Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogCEI-0202
ProductNameCyclopamine
EC No.
CAS No.4449-51-8
Source
CatalogCEI-0659
EC No.
CAS No.
Source
CatalogCEI-1165
ProductNamePF-5274857
EC No.
CAS No.1373615-35-0
Source
Online Inquiry
Name:
*Phone:
*E-mail Address:
Country:
Company/Institution:
*Products or Services Interested:
Quantity:
Project Description:
Our Products are Not Intended for Private Therapeutic Use!
*Verification Code:
Please input "enzymes"(case insensitive) as verification code.

Welcome! For price inquiries, please feel free to contact us through the form below through the form on the left side. We will get back to you as soon as possible.

Sitemap  Privacy Policy
Copyright ©2011 - 2017 Creative Enzymes.
Contact Us 45-1 Ramsey Road, Shirley, NY 11967, USA
Email: info@creative-enzymes.com
Tel: 1-631-562-8517 1-631-448-7888
Fax: 1-631-938-8127
Distributors To view the contact information for a specific location, select the desired country: