Products

Enzymes for Research, Diagnostic and Industrial Use

Staurosporine

Cat No.
CEI-0315
Description
Staurosporine (AM-2282, SSP) can potently inhibit protein kinase C with IC50 of 2.7 nM.
CAS No.
62996-74-1
Molecular Weight
466.53
Purity
>99%
Storage
2 years at -20 centigrade
Targets
PKC
Molecular Formula
C28H26N4O3
Chemical Name
9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3,2,1-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9alpha,10beta,11beta,13alpha)]-
Solubility
DSMO 4 mg/mL Water
In vitro
Staurosporine (AM-2282, SSP) can potently inhibit protein kinase C with IC50 of 2.7 nM. Staurosporine (AM-2282) can also inhibit NADPH-Oxidase activation. Besides inhibiting protein kinase C, staurosporine (AM-2282) also inhibit cyclic AMP-dependent kinase and the tyrosine kinase pp60src. In intact human neutrophils, staurosporine can potently block the action of the phorbol ester tumor promoters with nM concentrations, but shows no inhibition to the effects of phorbol 12,13-dibutyrate on epidermal growth factor binding in mouse primary epidermal cells. aurosporine is an effective inhibitor of the EGF-stimulated receptor tyrosine kinase. In both human epidermal carcinoma A431 cells and mouse Swiss 3T3 fibroblasts, staurosporine treatment causes enhancement in high affinity EGF binding and a decrease in the phosphorylation state of the unstimulated receptor.[2] Staurosporine (AM-2282, SSP) can stop progression of normal nontransformed cells in the G1 phase of the cell cycle.The target(s) of SSP is (are) either the p33cdk/cyclin E complex itself or other protein kinase(s), activated subsequent to the cyclin D but prior to the cyclin E restriction point, the activity of which is essential for cell transit through G1. Staurosporine at a concentration of 20 nM arrests normal diploid fibroblasts 3 h into G1, and staurosporine (2 nM) induces a new G1 arrest point at 6 h into G1.
Download Datasheet:



Inquiry
Realted Products
Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogCEI-0617
ProductNameGW 9662
EC No.
CAS No.22978-25-2
Source
CatalogCEI-0963
ProductNameGF-109203X
EC No.
CAS No.133052-90-1
Source
CatalogCEI-0969
ProductNameNPC-15437
EC No.
CAS No.141774-20-1
Source
Online Inquiry
Name:
*Phone:
*E-mail Address:
Country:
Company/Institution:
*Products or Services Interested:
Quantity:
Project Description:
Our Products are Not Intended for Private Therapeutic Use!
*Verification Code:
Please input "enzymes"(case insensitive) as verification code.

Welcome! For price inquiries, please feel free to contact us through the form below through the form on the left side. We will get back to you as soon as possible.

Sitemap  Privacy Policy
Copyright ©2011 - 2017 Creative Enzymes.
Contact Us 45-1 Ramsey Road, Shirley, NY 11967, USA
Email: info@creative-enzymes.com
Tel: 1-631-562-8517 1-631-448-7888
Fax: 1-631-938-8127
Distributors To view the contact information for a specific location, select the desired country: