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steroid 17α-monooxygenase

Cat No.
EXWM-0916
Description
Requires NADPH and EC 1.6.2.4, NADPH-hemoprotein reductase. A microsomal hemeprotein that catalyses two independent reactions at the same active site - the 17α-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis, and the conversion of the 17α-hydroxylated products via a 17,20-lyase reaction to form androstenedione and dehydroepiandrosterone, leading to sex hormone biosynthesis (EC 4.1.2.30, 7α-hydroxyprogesterone aldolase). The ratio of the 17α-hydroxylase and 17,20-lyase activities is an important factor in determining the directions of steroid hormone biosynthesis towards biosynthesis of glucocorticoid or sex hormones.
Form
Liquid or lyophilized powder
Enzyme Commission Number
CAS No.
9029-67-8
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Synonyms
steroid 17α-hydroxylase; cytochrome P-450 17α; cytochrome P-450 (P-450 17α,lyase); 17α-hydroxylase-C17,20 lyase; CYP17; CYP17A1 (gene name)
Reaction
a C21-steroid + [reduced NADPH-hemoprotein reductase] + O2 = a 17α-hydroxy-C21-steroid + [oxidized NADPH-hemoprotein reductase] + H2O;
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
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