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Enzymes for Research, Diagnostic and Industrial Use

TAE684 (NVP-TAE684)

Cat No.
CEI-0041
Description
TAE684 (NVP-TAE684) can inhibit ALK and LRRK2 kinase with IC50 of 3 nM and 7.8 nM.
CAS No.
761439-42-3
Molecular Weight
614.2
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
ALK, LRRK2
Molecular Formula
C30H40ClN7O3S
Chemical Name
5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine
Solubility
DMSO 3 mg/mL Water
In vitro
TAE684, a 2,4-dianilino-5-chloro-pyrimidine, is a ALK inhibitor and it also shows inhibitions to LRRK2 kinase. TAE684 can inhibit ALK and LRRK2 kinase with IC50 of 3 nM and 7.8 nM.
In vivo
TAE684 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3muM in cells and in mouse spleen and kidney, but not in brain, following oral doses of 10mg/kg.
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