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Enzymes for Research, Diagnostic and Industrial Use

TAK-700 R-form

Cat No.
CEI-1546
Product Overview
TAK-700 R-form is a highly selective inhibitor of 17, 20-lyase with IC50 value of 38nM. TAK-700 is a potent and selective inhibitor of the 17, 20-lyase activity of CYP17A1 which is responsible for androgen biosynthesis. Thus, TAK-700 is selected as a candidate for treatment of prostate cancer through reducing the adrenal androgen production. As an inhibitor of CYP17A1, the selectivity of TAK-700 is important to avoid causing the drug-drug interactions or side effects. TAK-700 shows potent inhibitory activity and high selectivity against 17, 20-lyase over other CYPs including 11-hydroxylase and CYP3A4. The IC50 values for 11-hydroxylase and CYP3A4 are above 1μM and above 10μM, respectively. Moreover, in a monkey model, the administration of TAK-700 is found to significantly reduce serum testosterone and DHEA levels.
CAS No.
752243-39-3
Molecular Weight
307.35
Purity
0.98
Storage
Store at-20°C
Targets
17, 20-lyase
Molecular Formula
C18H17N3O2
Chemical Name
6-[(7R)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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