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TTP 22
Cat No.
CEI-1563
Product Overview
TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor. Casein kinase 2 (CK2) noticeably stands out against a background of the kinase family due to its constitutive catalytic activity with the ability to phosphorylate more than 300 physiological substrates. These features make CK2 appear greatly diverse points of cell signaling pathways and be involved in processes leading to the development of various disorders, especially cancer. Thus, currently CK2 is regarded as druggable protein kinase target and can be used for the development of antitumor, anti-inflammatory and antiviral drugs.
CAS No.
329907-28-0
Molecular Weight
330.42
Purity
0.9819
Storage
Store at -20°C
Synonyms
TTP22; TTP-22
Targets
CK2
IC50
IC50= 0.1 μM; Ki= 40 nM
Molecular Formula
C16H14N2O2S2
Chemical Name
3-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylpropanoic acid
Solubility
Soluble in DMSO > 10 mM
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
In vitro
Kinetic studies of TTP 22 showed that activity of (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids moiety was a result of its competition with ATP molecule for the binding site. Inhibition constant (Ki) for TTP 22 was 40 nM. Initial in vitro tests of TTP 22 and it analog on four serine/threonine (ASK1, JNK3, Aurora A and Rock 1) and three tyrosine protein kinases (FGFR1, Met and Tie2) revealed their remarkable specificity towards CK2.
In vivo
So far, no animal in vivo study has been conducted for TTP 22.
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