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Tissue plasminogen activator from Human, Recombinant


Cat No.
NATE-0920
Description
Tissue plasminogen activator (abbreviated PLAT or tPA) is a secreted serine proteasewhich converts the proenzymeplasminogento plasmin, a fibrinolyticenzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migrationand tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysiswhich can result in thrombosisor embolism.
Abbr
tPA, Recombinant (Human)
Alias
tPA; PLAT
Source
CHO
Species
Human
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Product Overview
Tissue Plasminogen Activator Human Recombinant produced in CHO cells is a single, glycosylated polypeptide chain containing 527 amino acids and having a molecular mass of 59008.71 Dalton. tPA is a serine protease enzyme that converts plasminogen to plasmin. The tPA is purified by proprietary chromatographic techniques.
Enzyme Commission Number
EC 3.4.21.68
Activity
580,000 IU/mg
Molecular Weight
59008.71 Da
Purity
Greater than 98.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Stability
Lyophilized t-PA although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution tPA should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Buffer
Each mg of t-PA contains 1.7 gr L-arginine, 0.5 gr phosphoric acid and 4 mg tween 80.
Synonyms
Tissue-type plasminogen activator; EC 3.4.21.68; tPA; t-PA; t-plasminogen activator; TPA; T-PA
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Catalog
Product Name
EC No.
CAS No.
Source
Price
CatalogEXWM-4159
EC No.EC 3.4.21.68
CAS No.139639-23-9
Source
Related Protocols
Tissue Plasminogen Activator -Enzymatic Assay Protocol
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