Description
The enzyme UDP-glucose 4-epimerase (EC 5.1.3.2), also known as UDP-galactose 4-epimerase or GALE, is a homodimeric epimerase found in bacterial, fungal, plant, and mammalian cells. This enzyme performs the final step in the Leloir pathway of galactose metabolism, catalyzing the reversible conversion of UDP-galactose to UDP-glucose. GALE tightly binds nicotinamide adenine dinucleotide (NAD+), a co-factor required for catalytic activity.
Abbr
GalE, Recombinant (E. coli K12)
Enzyme Commission Number
EC 5.1.3.2
Purity
min 95% by SDS-PAGE
Unit Definition
One unit is defined as the amount of enzyme that catalyzes the formation of 1 μmol of UDP-Gal from UDP-Glc per minute at 37 °C.
Synonyms
Galactowaldenase; UDP-galactose 4-epimerase; Uridine diphosphate galactose 4-epimerase; Uridine diphospho-galactose-4-epimerase; UDP-glucose 4-epimerase; EC 5.1.3.2; UDP-galactose 4-epimerase; GALE
