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USP7/USP47 Inhibitor, P 22077

Cat No.
CEI-0696
Description
A cell-permeable inhibitor of the ubiquitin-specific protease (IC50 = 8.6 µM) and the closely related deubiquitinase (DUB) USP47. P22077 displays weak or no inhibition (EC₅₀ >50 µM) towards a panel of 14 isopeptidases and other proteases. Inhibits USP7-mediated p53 deubiquitination.
Alias
DUB inhibitor
Appearance
White to off-white solid
Product Overview
A USP7/USP47 inhibitor
CAS No.
1247819-59-5
Molecular Weight
264.3
Purity
>99%
Storage
-20 centigrade
Synonyms
DUB inhibitor
Targets
USP7, USP47
Molecular Formula
C 12 H 7 F 2 NO 3 S
Chemical Name
1-(5-(2,4-Difluorophenylthio)-4-nitrothiophen-2-yl)ethanone
Solubility
DMSO (60 mg/ml) of EtOH (2 mg/ml)
Shipping Conditions
Gel Pack
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EC No.
CAS No.882257-11-6
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