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VX-222 (VCH-222, Lomibuvir)
Cat No.
CEI-1577
Description
VX-222 is a potent and selective inhibitor of HCV RNA-dependent RNA polymerase with IC50 value of 0.94-1.2 μM.
Product Overview
VX-222, a derivative of thiophene-2-carboxylic acid, is a potent non-nucleoside inhibitor (NNI) of the hepatitis C virus (HCV) RNA polymerase, an enzyme regulating RNA synthesis by a de novo-initiated mechanism or by extension from a primed template, that binds to the thumb II allosteric pocket of HCV RNA-dependent RNA polymerase with hydrophobical interactions between the 4-methycyclohexanoyl group of VX-222 and L412, M423 and I482 of thumb II domain. VX-222 exhibits preferential inhibition against primer-dependent RNA synthesis rather than de novo-initiated RNA synthesis with 50% inhibition concentration IC50 values ranging from 0.011 to >5 μM in five different templates of RNA synthesis.
CAS No.
1026785-59-0
Molecular Weight
445.6
Purity
0.98
Storage
Store at -20°C
Synonyms
Lomibuvir, VCH222,VCH-222, VX222
Targets
HCV RNA polymerase
IC50
0.94-1.2 μM
Molecular Formula
C25H35NO4S
Chemical Name
5-(3,3-dimethylbut-1-ynyl)-3-[(4-hydroxycyclohexyl)-(4-methylcyclohexanecarbonyl)amino]thiophene-2-carboxylic acid
Solubility
Soluble in DMSO > 10 mM
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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