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Valsartan (Diovan)

Cat No.
CEI-0369
Description
Valsartan (Diovan) is an angiotensin II receptor antagonist with IC50 of ranging from 39.5 to 116 uM.
CAS No.
137862-53-4
Molecular Weight
435.52
Purity
>98%
Storage
2 years -20centigrade Powder
Targets
angiotensin II receptor
Molecular Formula
C24H29N5O3
Chemical Name
(2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl] methyl]amino]butanoic acid
Solubility
DMSO 87 mg/mL,Water
In vitro
valsartan is a potent, highly selective, and orally active antagonist at the angiotensin II (AII) AT1-receptor. Valsartan compets with [125I]-AII at its specific binding sites in rat aortic smooth muscle cell membranes (AT1-receptor subtype) with a Ki of 2.38 nM, but is about 30,000 times less active in human myometrial membranes (AT2-receptor subtype).
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