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Vardenafil Hydrochloride Trihydrate (BAY38-9456)

Cat No.
CEI-0237
Description
Vardenafil
Alias
Levitra, Vivanza
CAS No.
224785-90-4
Molecular Weight
579.11
Purity
>99%
Storage
2 years at -20centigrade Powder
Synonyms
Levitra, Vivanza
Targets
phosphodiesterase type 5
Molecular Formula
C23H32N6O4S.HCl.3H2O
Chemical Name
2-(2-ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)phenyl)-5-methyl-7-propylimidazo[1,5-f][1,2,4]triazin-4(3H)-one hydrochloride trihydrate
Solubility
DMSO 116 mg/mL, Water 116 mg/mL, Ethanol 20 mg/mL
In vitro
Vardenafil Hydrochloride Trihydrate (Vivanza) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. Vardenafils indications and contra-indications are the same as with other PDE5 inhibitors; it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis). Structurally, the difference between the vardenafil molecule and sildenafil citrate is a nitrogen atoms position and the change of sildenafils piperazine ring methyl group to an ethyl group. Chronic vardenafil treatment improves erectile function via structural maintenance of penile corpora cavernosa in rats with acute arteriogenic erectile dysfunction.
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