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WAY-100635 HCl

Cat No.
CEI-0212
Description
WAY-100635 HCl
CAS No.
"146714-97-8
Molecular Weight
531.95
Purity
>99%
Storage
2 years at -20 centigrade
Targets
5-HT
Molecular Formula
C25H34N4O2.3HCl
Solubility
No
In vitro
The antagonism exerted by WAY 100635 is fully surmounted by increasing the concentration of 5-HT to 300 uM with an IC50 of 0.95 nM. In hippocampal slices, WAY 100635 (0.5 nM -10 nM) does not alter the resting membrane potential or the membrane input resistance of intracellularly recorded CA1 pyramidal cells. However, WAY 100635 completely prevents not only the hyperpolarization, with an IC50 of 1.3 nM, but also the decrease in membrane input resistance produced by 5-HT and 5-carboxamidotryptamine with IC50 of 22.5 uM and 50 nM, respectively.
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