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WEHI-539

Cat No.
CEI-1580
Product Overview
WEHI-539 is a small-molecule inhibitor of BCLXLwith an IC50 value of 1.1 nM. WEHI-539 was designed as a BCL-XLinhibitor with high affinity. It interacted the with the binding groove of BCL-XLwith a Kd value of 0.6 nM. In MEF cells lacking MCL-1, WEHI-539 induced apoptosis which was evidenced by the release of mitochondrial cytochrome cand caspase-3 processing. In BCL-XLoverexpressed MEF cells, WEHI-539 showed EC50 value of 0.48 μM. WEHI-539 also significantly induced apoptosis of the platelets purified from mice. Besides that, WEHI-539 can not kill MEF cells lacking BAK because the cell death mediator BAK is regulated by BCL-XLand MCL-1.
CAS No.
1431866-33-9
Molecular Weight
583.72
Purity
0.98
Storage
Store at -20°C
Synonyms
WEHI539,WEHI 539
Targets
Bcl-xL
IC50
1.1 nM
Molecular Formula
C31H29N5O3S2
Chemical Name
5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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