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Waglerin-1

Cat No.
CEI-1180
Description
Waglerin-1 is a 22 amino acid peptide toxin isolated from the Southeast Asian snake Trimeresurus wagleri. Two other similar peptides named Waglerin-2 and 3 are isolated from the same snake species. Waglerin-1 selectively blocks the nAChRε subunit with an IC50 of 50 nM and is a potent blocker of muscle nAChR. Waglerin-1 is also a modulator of GABA(A) receptors with potentiating and suppressing effects. Its IC50 and EC50 value is 24 μM.
Abbr
Waglerin-1
Source
Synthetic peptide
Product Overview
A Potent Blocker of nAChR and a Modulator of GABA(A) Receptors
Molecular Weight
2520 Da
Purity
>99%
Storage
Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Synonyms
Waglerin-I, Wtx-1, Lethal peptide I
Targets
nAChR, GABA(A) receptors
Molecular Formula
C112H175N37O26S2
Amino Acid Sequence
GGKPDLRPCHPPCHYIPRPKPR
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