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XAV939

Cat No.
CEI-0675
Description
A Tankyrase (TNKS) inhibitor (IC50 = 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the µ-catenin-dependent colon carcinoma cell line DLD-1.
Appearance
White to off-white solid
Product Overview
A Tankyrase (TNKS) inhibitor
CAS No.
284028-89-3
Molecular Weight
1429.15
Purity
>98
Storage
+4 centigrade
Targets
TNKS
Molecular Formula
C₁₄H₁₁F₃N₂OS
Chemical Name
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one
Solubility
DMSO (10 mM) and water (50 mM)
Shipping Conditions
RT
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