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Y-39983 dihydrochloride

Cat No.
CEI-1588
Product Overview
Y-39983 dihydrochloride is a novel and selective inhibitor of ROCK family with IC50 value of 3.6nM for ROCK. Y-39983 dihydrochloride has shown a selective inhibitor of Rho-associated coiled coil-forming protein kinase (ROCK) with IC50 values of 3.6nM, 0.42μM and 0.81μM for ROCK, PKC and CaMKII, respectively. Apart from these, Y-39983 has been reported to relax the ciliary arteries of precontracted isolated rabbit in vitro. In addition, Y-39983 has been found to increase optic-nerve-head blood flow by laser speckle flowmetry. Moreover, Y-39983 lowered the intraocular pressure (IOP) in a dose-dependent fashion in the eyes of rabbits and monkeys.
CAS No.
173897-44-4
Molecular Weight
353.25
Purity
0.98
Storage
Store at-20°C
Targets
ROCK
Molecular Formula
C16H18Cl2N4O
Chemical Name
4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide; dihydrochloride
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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