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ZM 336372

Cat No.
CEI-0148
Description
ZM 336372 can potently and selectivley inhibit c-Raf with IC50 of 70 nM.
CAS No.
208260-29-1
Molecular Weight
389.45
Purity
>99%
Storage
2 years at -20 centigrade
Targets
c-Raf
Molecular Formula
C23H23N3O3
Chemical Name
Benzamide, 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-
Solubility
DSMO 78 mg/mL Water
In vitro
ZM 336372 can potently and selectivley inhibit c-Raf with IC50 of 70 nM. But exposure of cells to ZM 336372 induces > 100-fold activation of c-Raf. The activation of c-Raf induced by ZM 336372 does not increase the GTP-loading of Ras. And this activation can not be blocked by inhibiting of the MAPK cascade, PKC or PI3K signaling. ZM 336372 does not prevent growth factor or phorbol ester induced activation of MKK1 or p42 MAPK/ERK2, or reverse the phenotype of Ras- or Raf-transformed cell lines. The only other protein kinase inhibited by ZM 336372 out of 20 tested was SAPK2/p38. In addition, the down-regulation of Pgp following BSO treatment can be abolished by c-Raf inhibitor ZM 336372.
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