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Lipoprotein Lipase Activator
Cat No.
COEC-108
Description
Lipoprotein Lipase Activator is a cell-permeable benzylphosphonate derivative that selectively induces lipoprotein lipase (LPL) mRNA and protein levels, but does not exhibit PPARα or PPARγ agonistic activities. Lipoprotein Lipase Activator lowers serum lipid levels and plasma triglycerides with concomitant elevation in high-density lipoprotein cholesterol (HDL-C) in animal models. Lipoprotein Lipase Activator also induces fatty acid oxidation related enzymes, lowers free fatty acids (FFA), and minimizes fat accumulation. Also reported to suppress the plasma levels of TNF-a and COX-2 and displays anti-tumor properties.
Applications
An inducer of lipoprotein lipase mRNA
Form
Solid
CAS No.
133208-93-2
Molecular Weight
451.25
Purity
≥95%
Synonyms
NO-1886; Diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate; Ibrolipim
Molecular Formula
C19H20BrN2O4P
Melting Point
90.27° C (Predicted)
Solubility
Soluble in DMSO (≥20 mg/ml).
Boiling Point
512.47° C at 760 mmHg (Predicted)
Refractive Index
~1.72 (Predicted)
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