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Enzyme Activity Measurement for Fructuronate Reductase Using Spectrophotometric Assays

Creative Enzymes is an expert in enzyme activity measurement for fructuronate reductase using spectrophotometric assays. We have a group of superior scientists who have been working on enzyme activity assays for years. The unique advantage on our spectrophotometric analysis allows us to outpace our competitors and assures the reliability of the test results.

Fructuronate reductase (EC1.1.1.57) is an enzyme that catalyzes the reversible oxidation of D-mannonate to D-fructuronate in the presence of NAD+. And the enzyme also transforms D-tagaturonate to D-altronate. This enzyme is a member of the oxidoreductase  which catalyze the CH-OH group of the substrate and use NAD+ or NADP+ as the cofactor. The systematic name of this enzyme class is D-mannonate:NAD+ 5-oxidoreductase, which is also known as mannonate oxidoreductase, mannonic dehydrogenase, D-mannonate dehydrogenase, and D-mannonate:NAD+ oxidoreductase. Fructuronate reductase is involved in multiple pathways:

This enzyme is involved in the D-fructuronate degradation pathway, which is a critical part of the superpathway of β-D-glucuronide and D-glucuronate degradation. Escherichia coli can use β-D-glucuronides, D-glucuronate, or D-fructuronate as the sole carbon source for growth. The initial step in the degradation of β-glucuronides is hydrolysis   to yield D-glucuronate, which is subsequently isomerized to D-fructuronate. D-fructuronate then undergoes an NADH-dependent reduction to D-mannonate catalyzed by fructuronate reductase. At this point, three pathways converged (the superpathway of β-D-glucuronide, D-glucuronate degradation, and D-galacturonate degradation I pathway). It is obvious that fructuronate reductase plays a critical role in bacterial growth and metabolism. Due toits valuable function, the measurement of catalytic activity for fructuronate reductase is necessary to a variety of research and development activities in health care and biotechnology. Creative Enzymes is proud to provide the unparalleled service of spectrophotometric activity assays for fructuronate reductase.

We have the most advanced spectrophotometric instruments in the world, backed by the unique techniques of assay development. Creative Enzymes is sincerely looking forward to build solid collaboration with the customers.. We  constantly provide satisfactory services and products, and expect for the chance of perfecting your business in the future.

Enzyme Activity Measurement for Fructuronate Reductase Using Spectrophotometric Assays Figure: The crystal structure of fructuronate reductase from E. coli CFT073 (EFI TARGET EFI-506389) complexed with NADH and D-mannonate. PDB: 4IM7

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