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Polynucleotide phosphorylase

Official Full Name
Polynucleotide phosphorylase
Background
Polynucleotide phosphorylase is a bifunctional enzyme with a phosphorolytic 3' to 5' exoribonuclease activity and a 3'-terminal oligonucleotide polymerase activity. It is involved on mRNA processing and degradation in bacteria, plants, and in humans. In humans, the enzyme is encoded by the PNPT1 gene. In its active form, the protein forms a ring structure consisting of three PNPase molecules. Each PNPase molecule consists of two RNase PH domains, an S1 RNA binding domain and a K-homology domain. The protein is present in bacteria and in the chloroplasts and mitochondria of some eukaryotic cells. In eukaryotes and archaea, a structurally and evolutionary related complex exists, called the exosome. The same abbreviation (PNPase) is also used for another, otherwise unrelated enzyme, Purine nucleoside phosphorylase.
Synonyms
PNPase
Catalog Product Name EC No. CAS No. Source Price
NATE-1908 Native Bacillus stearothermophilus Polynucleotide Phosphorylase EC 2.7.7.8 9014-12-4 Bacillus stearo... Inquiry
EXWM-3292 polyribonucleotide nucleotidyltransferase EC 2.7.7.8 9014-12-4 Inquiry
NATE-0609 Polynucleotide phosphorylase from Human, Recombinant EC 2.7.7.8 9014-12-4 E. coli Inquiry
NATE-0610 Polynucleotide phosphorylase from Synechocystis sp., Recombinant EC 2.7.7.8 9014-12-4 E. coli Inquiry
NATE-0608 Polynucleotide Phosphorylase from Escherichia coli, Recombinant EC 2.7.7.8 9014-12-4 E. coli Inquiry