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Polynucleotide phosphorylase

Official Full Name
Polynucleotide phosphorylase
Background
Polynucleotide phosphorylase is a bifunctional enzyme with a phosphorolytic 3' to 5' exoribonuclease activity and a 3'-terminal oligonucleotide polymerase activity. It is involved on mRNA processing and degradation in bacteria, plants, and in humans. In humans, the enzyme is encoded by the PNPT1 gene. In its active form, the protein forms a ring structure consisting of three PNPase molecules. Each PNPase molecule consists of two RNase PH domains, an S1 RNA binding domain and a K-homology domain. The protein is present in bacteria and in the chloroplasts and mitochondria of some eukaryotic cells. In eukaryotes and archaea, a structurally and evolutionary related complex exists, called the exosome. The same abbreviation (PNPase) is also used for another, otherwise unrelated enzyme, Purine nucleoside phosphorylase.
Synonyms
PNPase

Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogNATE-1908
EC No.EC 2.7.7.8
CAS No.9014-12-4
SourceBacillus stearo...
CatalogEXWM-3292
EC No.EC 2.7.7.8
CAS No.9014-12-4
Source
CatalogNATE-0609
EC No.EC 2.7.7.8
CAS No.9014-12-4
SourceE. coli
CatalogNATE-0610
EC No.EC 2.7.7.8
CAS No.9014-12-4
SourceE. coli
CatalogNATE-0608
EC No.EC 2.7.7.8
CAS No.9014-12-4
SourceE. coli
Related Protocols
polynucleotide phosphorylase -Enzymatic Assay Protocol
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