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TPO

Official Full Name
TPO
Background
Thyroid Peroxidase (TPO) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. Its identity with the formerly so-called "microsomal antigen" has been shown several years ago. As an integral membrane glycoprotein it is restricted to the apical plasma membrane of the follicular epithelial cells and comprises two identical subunits of approx. 100 kDa molecular weight. The hemoprotein TPO plays a key role in the thyroid hormone biosynthesis by catalysing both the iodination of tyrosyl residues and the coupling of iodotyrosyl residues in thyroglobulin (TG) to form precursors of the thyroid hormones T4 and T3.
Synonyms
Thyroid peroxidase; EC 1.11.1.8; TPO; MSA; TPX; iodotyrosine deiodase; iodinase; iodoperoxidase (heme type); iodide peroxidase-tyrosine iodinase; iodotyrosine deiodinase; monoiodotyrosine deiodinase; thyroperoxidase; tyrosine iodinase; iodide peroxidase

Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogNATE-0919
EC No.
CAS No.9031-28-1
SourceSf9 insect cell...

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