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Native Escherichia coli Diacylglycerol Kinase

Cat No.
NATE-0181
Description
Diacylglycerol kinase (DGK or DAGK) is a family of enzymes that catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA) utilizing ATP as a source of the phosphate. In non-stimulated cells, DGK activity is low allowing DAG to be used for glycerophospholipid biosynthesis but on receptor activation of the phosphoinositide pathway, DGK activity increases driving the conversion of DAG to PA. As both lipids are thought to function as bioactive lipid signaling molecules with distinct cellular targets, DGK therefore occupies an important position, effectively serving as a switch by terminating the signalling of one lipid while simultaneously activating signalling by another.
Abbr
DAGK, Native (E. coli)
Alias
DGK; DAGK
Source
E. coli
Applications
Diacylglycerol Kinase from Escherichia coli has been used in a study to assess the antagonistic regulation of dgkA and plsB genes of phospholipid synthesis by multiple stress responses in Escherichia coli. Diacylglycerol Kinase from Escherichia coli has also been used in a study to identify an alcohol binding site in the first cysteine-rich domain of protein kinase Cdelta.
Form
suspension
Enzyme Commission Number
EC 2.7.1.107
CAS No.
60382-71-0
Molecular Weight
mol wt 13.7 kDa
Unit Definition
One unit will phosphorylate 1.0 μmol of diacylglycerol per minute at 25°C.
Stability
−70°C
Buffer
Supplied as a turbid membrane suspension in 25 mM sodium phosphate buffer, pH 7.0, 20.0% glycerol, 1 mM DTT.
Pathway
Glycerolipid metabolism, organism-specific biosystem; Glycerolipid metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem
Synonyms
Diacylglycerol Kinase; DGK; DAGK; EC 2.7.1.107; Diacylglycerol kinase (ATP); sn-1,2-Diacylglycerol kinase
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CatalogEXWM-2953
EC No.EC 2.7.1.107
CAS No.60382-71-0
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