Alanine transaminase (ALT) is a transaminase enzyme (EC 220.127.116.11). It is also called alanine aminotransferase (ALAT) and was formerly called serum glutamate-pyruvate transaminase (SGPT) or serum glutamic-pyruvic transaminase (SGPT). ALT is found in plasma and in various body tissues, but is most common in the liver. It catalyzes the two parts of the alanine cycle. Serum ALT level, serum AST (aspartate transaminase) level, and their ratio (AST/ALT ratio) are commonly measured clinically as biomarkers for liver health. The tests are part of blood panels.
Human Cardiac Tissue
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Alanine Transaminase, also commonly known as Serum Glutamate Pyruvate Transaminase is an enzyme involved in the synthesis of the amino acid alanine. It is found in a wide variety of tissues and although the highest concentrations are in the liver, it is also found in cardiac tissue. Within the diagnostics industry, the ALT enzyme is regularly used in the analysis of liver function, where liver damage results in raised ALT levels.
Enzyme Commission Number
Alanine transaminase; ALT; EC 18.104.22.168; alanine aminotransferase; ALAT; glutamic-pyruvic transaminase; glutamic-alanine transaminase; GPT; β-alanine aminotransferase; alanine-α-ketoglutarate aminotransferase; alanine-pyruvate aminotransferase; glutamic acid-pyruvic acid transaminase; glutamic-pyruvic aminotransferase; L-alanine aminotransferase; L-alanine transaminase; L-alanine-α-ketoglutarate aminotransferase; pyruvate transaminase; pyruvate-alanine aminotransferase; pyruvate-glutamate transaminase