The enzyme catalyses electron transfer to cytochrome P450. This system plays a major role in detoxification of drugs and xenobiotics, activation of carcinogens, and metabolism of endogenous substrates such as steroids.
CPR, Native (Rabbit)
buffered aqueous glycerol solution. Solution in 30 mM potassium phosphate buffer, pH 7.7, and 0.1 mM EDTA containing 50% (v/v) glycerol.
Enzyme Commission Number
25-75 units/mg protein (Bradford)
mol wt ~80 kDa
One unit will catalyze the reduction of 1.0 μmole of cytochrome c by NADPH per min at pH 7.7 at 30°C.
EC 220.127.116.11; NADPH:ferrihemoprotein oxidoreductase; NADPH:hemoprotein oxidoreductase; NADPH:P450 oxidoreductase; P450 reductase; CPR; 9039-06-9; FAD-cytochrome c reductase; NADPH-dependent cytochrome c reductase; NADPH:P-450 reductase