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Protein Kinase Cζ isozyme from human, Recombinant

Cat No.
NATE-0625
Description
Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and γ. Members of the second family are phospholipid-dependent but Ca2+-independent, and include PKCδ, ε, η, and θ. Members of the third family are not activated by either DAG or phorbol esters and include PKCξ, μ, and ι.
Abbr
PRKCZ, Recombinant (Human)
Alias
PRKCZ; PKC2
Source
Baculovirus infected insect cells
Species
Human
Form
buffered aqueous solution; Solution in 20 mM HEPES, pH 7.5; 2 mM EDTA, 2 mM EGTA, 5 mM DTT, 250 mM NaCl, 0.05% Triton X-100, and 50% glycerol.
Enzyme Commission Number
EC 2.7.1.37
Molecular Weight
mol wt 76-80 kDa by SDS-PAGE
Purity
> 75% (SDS-PAGE)
Storage
−70°C
Pathway
CDC42 signaling events, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Ceramide signaling pathway, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; EGFR1 Signaling Pathway, organism-specific biosystem
Function
ATP binding; insulin receptor substrate binding; metal ion binding; nucleotide binding; protein binding; protein kinase C activity; protein kinase activity; protein serine/threonine kinase activity; zinc ion binding
Synonyms
PRKCZ; protein kinase C, zeta; protein kinase C zeta type; PKC2; PKC-ZETA; EC 2.7.1.37

"PKC" Total Products Page

Catalog Product Name EC No. CAS No. Source Price
NATE-0573 Native Rat Protein Kinase C EC 2.7.1.37 141436-78-4 Rat brain Inquiry
NATE-0574 Protein kinase Cα isozyme human, Recombinant baculovirus infected insect cells Inquiry
NATE-0575 Protein Kinase Cε isozyme human, Recombinant EC 2.7.1.37 baculovirus infected insect cells Inquiry
NATE-0576 Protein Kinase Cη isozyme human, Recombinant EC 2.7.1.37 baculovirus infected insect cells Inquiry

Our Products Cannot Be Used As Medicines Directly For Personal Use.

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