Pyrimidine nucleoside phosphorylase (PyNPase) is a glycosyltransferase that catalyzes the conversion of pyrimidine nucleoside and phosphate to a pyrimidine base and α-D-ribose 1-phosphate. PyNPase plays a significant role in breast cancer angiogenesis.
Pyrimidine nucleoside phosphorylase (PyNPase) may be used as a marker to predict the malignant potential of breast cancer, especially lymph node metastasis. PyNPase is used to study breast cancer, specifically its role in angiogenesis. This product is recombinant and expressed in E. coli (> 50 U/mL).
Enzyme Commission Number
Type I, > 50 U/mL; Type II, > 1300 U/mL.
One unit will convert 1 μmole each of thymidine and phosphate to thymine and 2-deoxyribose 1-phosphate per minute at pH 7.4 and 25°C
Pyrimidine nucleoside phosphorylase; EC 184.108.40.206; Py-NPase; 9055-35-0; pdp (gene name); PyNPase