Description
SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC50 = 19 µM). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the β-galactosidase activity (IC50 = 1.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Product Overview
A Hedgehog (Hh) signaling pathway antagonist
Molecular Formula
C 27 H 28 ClN 5 O 2
Chemical Name
3-(3-(4-Fluorophenyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl-N-(3-methylphenethyl)propanamide
Shipping Conditions
Gel pack
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