Industrial Enzymes for Chemical Synthesis and Green Chemistry

Client Challenge:

A chemical manufacturer needed improved selectivity in a critical transformation to reduce byproduct formation and downstream purification burden.

Our Approach:

• Aligned enzyme activity assays to reaction-relevant substrates and operating conditions.
• Optimized upstream parameters and downstream handling to preserve catalytic performance.
• Implemented batch consistency testing to protect selectivity outcomes across lots.

Outcome:

• Improved reaction consistency and reduced variability between manufacturing lots.
• Supported pilot-to-supply transition for scalable industrial biocatalysis.

Client Challenge:

A solvent-containing synthesis step required stable enzyme performance during storage and in-use handling, with minimal activity drift between lots.

Our Approach:

• Defined stability testing reflecting co-solvent exposure and temperature excursions.
• Developed a formulation strategy and packaging guidance to protect activity during logistics.
• Established COA-ready QC and lot comparability endpoints for ongoing supply.

Outcome:

• Delivered a stable enzyme format suitable for plant handling and shipping.
• Enabled predictable performance supported by documented batch consistency testing.

Client Challenge:

A client required pilot lots for reaction validation and a clear path to manufacturing supply, with consistent activity units and reproducible performance across lots.

Our Approach:

• Developed a scale-aware fermentation and downstream workflow with defined critical parameters.
• Established release specifications using reaction-relevant activity assays and stability indicators.
• Performed batch comparability testing to confirm lot-to-lot consistency prior to supply expansion.

Outcome:

• Supported pilot validation with documented QC outputs and reproducible supply lots.
• Provided a manufacturing-ready documentation package to support ongoing procurement and operations.